“We used Pebble to perform an early preclinical evaluation of novel polysulphide nanoparticle formulation with potent antioxidant properties. Pebble designed a series of experiments to replicate transplant reperfusion, and generated a clinically relevant datapack within a matter of weeks, demonstrating that our NPs were both safe and effective. We then requested additional studies to delineate optimal dosing and mechanism of action. Pebble further developed a bespoke kidney platform and confirmed our NPs were scavenging ROS and reducing reperfusion-associated inflammation 

What impressed me the most was the efficiency of Pebble. They took care of experimental designs, performed all surgical procedures independently, collected and analysed data, and helped us prepare a manuscript under review in a high impact journal. This preclinical work is directly supporting our next phase of research, including an ambitious investment plan. It’s remarkable that the entire study was completed at a fraction of the cost of a large animal model, with a more streamlined regulatory process fully handled by Pebble. We will definitely use Pebble again in future endeavours.”

– Professor Richard D’Arcy

Department of Biomedical Engineering

Vanderbilt University, Nashville, USA