Careers

Research that reaches patients, not just publications.

Pebble is where difficult problems in medicine come to be solved. We develop technologies that affect hundreds of thousands of patients annually, resolve clinical controversies that have persisted for decades, and take early innovations that don't work and turn them into therapies that do.

We are not a contract research organisation. We are an innovation house. The work that emerges from this place changes clinical practice.

Our team includes physiologists, engineers, perfusionists, data scientists, and clinicians. What unites them is the conviction that research should serve patients, not careers. We don't follow the traditional academic pathway where success is measured in grants and publications. We measure success in problems solved and lives improved.

We operate from a 400-year-old dairy farm with state-of-the-art infrastructure, running complex studies around the clock. We never use laboratory animals. Our living-organ systems set new standards for predicting human responses to therapies and devices.

Creating Opportunity

Through the Pebble Institute, we offer placements, apprenticeships, and training programmes specifically targeting people who have ability but lack opportunity. We believe the next generation of translational scientists should be encouraged to pursue work that has direct, positive impact on society. If that describes you, we want to hear from you.

Current Posts

Permanent | £26,000 - £30,000 + bonus | Pension | Staff Share Scheme
Are you a brilliant graduate scientist looking for work that genuinely matters?
Pebble evaluates the world's most innovative therapies using living organs maintained outside the body, perfused with blood and functioning as they would in a living patient. The data we generate helps determine which therapies advance to patients.
What You’'ll Do:
In any given week you could test a potentially curative gene therapy, an advanced life-support system, or a brain-computer interface that brings sensation to a biorobotic limb. You might evaluate nanoparticles, develop new trauma models, test a moonshot technology, or a bioactive compound found in a tropical rainforest.
You'll perform experimental surgery, conduct critical care monitoring, physiological analysis, immune profiling, and use AI approaches to study the effects of therapies in ways that directly replace primate studies. Every experiment matters.
Who You’ll Work With:
Our team is truly multidisciplinary: experimental surgeons, clinical surgeons, perfusionists, immunologists, engineers, physiologists. We are unconventional, curious, inventive and collaborative. We solve challenging problems, disrupt the boring, and reject dogma.
We are selective about who we work with, partnering only with the most innovative drug and device developers in the world.
Who You Are:
A first-class graduate scientist in life sciences or engineering who questions why things are done the way they've always been done. Intellectually curious, with motivation and stamina, who can thrive in controlled chaos where every experiment matters.
Requirements:
• First-class degree in life sciences or engineering
• Full UK driving licence
• Commitment to shift work including nights, early mornings, and late shifts - Pebble doesn't sleep!

Permanent | £30,000–£35,000 + bonus | Pension | Staff Share Scheme
For scientists ready to lead.
You have a PhD or equivalent research experience and you're looking for somewhere your expertise will be used on problems that matter. At Pebble, you'll design and lead complex experimental programmes, develop novel methodologies, and generate data that determines whether therapies advance to patients.
What You’ll Do:
You might lead a study evaluating a gene therapy's effects on human kidney function, develop a new model for assessing immunological tolerance, or work with our engineering team to refine perfusion protocols that extend organ viability. You'll mentor junior scientists, contribute to study design for partners ranging from early-stage biotechs to major pharmaceutical companies, and help shape the scientific direction of a rapidly growing organisation.
Who You’ll Work With:
You'll work closely with experimental surgeons, perfusionists, immunologists, and data scientists. The environment is collaborative but demanding: we run studies around the clock and every dataset matters.
Who You Are:
Someone who can think independently, troubleshoot under pressure, and communicate complex findings clearly.
Requirements:
• PhD in a relevant life science or equivalent research experience
• Demonstrated ability to design and execute complex experiments
• Strong analytical and communication skills
• Full UK driving licence
• Willingness to work flexibly including occasional nights and weekends

Permanent | £27,000 pro rata | Pension | Staff Share Scheme
Supporting the operational side of a growing biotech.
As we expand, we need someone to keep everything running smoothly. This is a hands-on role supporting the whole business.
What You’ll Do:
You'll manage supplies and equipment orders, handle correspondence, keep our accounting software current, coordinate schedules, and organise documentation. You'll support HR functions including drafting job descriptions, placing adverts, reviewing applicants, and onboarding new starters. You'll organise board meetings, prepare agendas and board packs, and produce minutes. On the finance side, you'll raise purchase orders and sales invoices and handle general bookkeeping.
The Practicalities:
Three days per week, four to five hours per day (days flexible). On-site at the Pebble Farm.
You must be organised, proactive, and comfortable working independently. You don't need a science background, but you do need to be unfazed by working alongside experimental surgery and life-support systems. Attention to detail matters. So does common sense.
Requirements:
• 2–3 years of office management experience
• Highly organised and efficient
• Self-motivated and diligent at working independently
• Good understanding of Office 365, finance software and other business systems

We're always interested in hearing from experimental surgeons, perfusionists, biomedical engineers, data scientists, laboratory scientists, operations specialists, and the unexpected, who want to be part of what we're building. Tell us why you want to work at Pebble and attach your CV and cover letter below or email to careers@pebble.bio.

Permanent | Pension | BSc (Hons) Biological Scientist at Manchester Metropolitan University
Train to become a qualified laboratory scientist while earning a degree.
This is a four-year apprenticeship combining hands-on work at Pebble with study at Manchester Metropolitan University. You'll graduate with a BSc (Hons) in Biological Science and real experience working on studies that determine which therapies advance to patients.
What You'll Do:
You'll prepare solutions for perfusion experiments, assist in building ex vivo perfusion circuits, perform cell saving, collect and process samples, and assist in all aspects of our perfusion studies. You'll learn surgical techniques, arterial blood gas analysis, sample processing, data analysis, and protocol development.
You'll attend laboratory meetings to discuss experimental plans, contribute to monthly presentations, and work on quality improvement projects. At least 20% of your time will be dedicated to studying for your degree.
Who You Are:
Curious, organised, and motivated. Comfortable working with organs and biological materials. Unfazed by shift work - Pebble runs experiments around the clock.
Requirements:
• 5 GCSEs including Maths, Science and English (Grade 4 or above)
• 2 or more A-Levels including Biology or Chemistry (minimum 96 UCAS points) desirable
• Comfortable working shifts including nights, early mornings, and occasional weekends
Start date: September 2026