LIVING-ORGAN Systems

A novel, translatable platform to rapidly assess your innovations

Pebble’s LIVING-ORGAN systems integrate advanced life support with innovation, transforming preclinical research with rapid, cost-effective solutions.

We DO NOT use laboratory animals. Instead, we support local farmers in rearing pigs to the highest husbandry standards. We use porcine organs and all biological material utilised is surplus to the food industry.

Blood is loaded into a central reservoir and recirculated via a pump, passing through an oxygenator. These components form our perfusion circuit.

Once warmed, organs are then attached to the perfusion circuit via arteries & veins.

Oxygenated blood is then circulated through the organ, restoring full function & metabolism outside of the body.

Example – Pebble’s LIVING-KIDNEY System

Bespoke LIVING-ORGAN systems can be designed in the following organs:

Pebble’s LIVING-ORGAN systems are highly complex, so we’ve created an animation to explain how they work.

Applications

Pebble’s LIVING-ORGAN systems can be used to test any innovation, as well as the ability to induce a variety of injuries. We are able to do this whilst monitoring an array of parameters comparable to the patient.

This is NOT a limited list. Bespoke protocols can be produced to suit your individual needs.

Pebble's ALPHA-BETA Test

As you move along the R&D pathway from early asset development to clinical trial submission, your testing methodology can hold things up – whether that’s poor efficacy translation from small animal models, adverse effects or simply a resource issue.

Pebble’s LIVING-ORGAN systems provide a unique alternative to traditional preclinical techniques.

Why Choose Pebble's LIVING-ORGAN Systems?

When you decide to work with us, you get full access to Pebble’s LIVING-ORGAN systems and our ALPHA-BETA test.

With this, we take you from early testing to clinical trial in less time, at lower costs and with better results.

Enhanced Efficiency

Your R&D process is streamlined, saving you time & resources.

Iterative Refinement

We identify & solve major issues early on to mitigate risk & delays.

Regulatory Success

We work closely with you to generate data tailored to regulatory requirements, easing the path to clinical trial approval.

Ethical Approach

LIVING-ORGAN systems does not use laboratory animals – all material is surplus biological material from the food industry.

Cost Saving

The complete lack of laboratory animals significantly reduces costs – that’s roughly an 80% cost-saving compared to large animal in vivo experiments.

Time Saving

Your study can be started in days and completed in weeks, rather than months or years.

Expertise

We’re led by James Fildes, CEO & CSO, and a Professor of Experimental Surgery. We’re supported by scientists with years of expertise in perfusion, clinical surgery, immunology & data analysis.