What We Offer
The Pebble Team has extensive experience in organ and tissue perfusion, developing LIVING-ORGAN systems incorporating a variety of organs. Our platforms replicate in-vivo physiology, enabling translatable testing of therapies and innovations.
Our perfusionists are keen to push the boundaries of scientific research, and can build complex, bespoke LIVING-ORGAN systems tailored to your needs. If you have a model in mind, no matter the complexity, please get in touch.
What Are LIVING-ORGAN Systems?
The Pebble LIVING-ORGAN System involves removing organs and tissues from the body and attaching them to a circuit which replicates in-vivo physiology. Tissues are perfused with blood-based solutions at physiological pressures and flows, using state-of-the-art levitating centrifugal pumps. Oxygenation and carbon dioxide clearance are performed by the addition of an oxygenator, and normothermia (normal body temperature) is maintained throughout.
For prolonged perfusion, nutritional support is infused. As a result of our highly complex circuits and protocols, organ function and metabolism are perfectly preserved.
In each of our models, kidneys urinate, livers secrete enzymes, lungs breathe, hearts beat, the muscles, fascia, and skin of a limb physiologically metabolise glucose and lactate. The circulating immune system corresponds closely with in-vivo, responding to stimuli such as LPS and infectious organisms.
Using these models, we can test any intervention and induce a wide range of injuries, while monitoring parameters that are comparable to the patient. This includes deep haemodynamic and biomarker profiling, as well as detailed functional assessment, all in real time.
Pebble’s LIVING-ORGAN systems are highly complex, so we’ve created an animation to explain how they work.
Our Platforms
Transplant
Cell & Gene Therapies
Kidney
Liver
Eye
Dermatology
Limb
Multi-Organ
Blood
Spleen
Lungs
Heart
Pancreas
Why Choose Pebble
Join the Waiting List!
Our systems are in high demand as we move towards the industry gold standard. View our platforms below and join our waiting list to access globally unique resources.
